By Dr. Chris Dennis | Chief Medical Officer
Sublocade vs. Vivitrol vs. Brixadi: Key Differences Explained
When it comes to treating opioid use disorder, medications like Sublocade, Vivitrol, and Brixadi often come up. Each can be effective, but they work in very different ways. Let’s break down the difference between Sublocade, Vivitrol, and Brixadi to help patients, families, and professionals make informed choices.
What is Sublocade1?
Sublocade is an injectable form of buprenorphine that helps treat opioid use disorder. It works by partially activating opioid receptors in the brain, which helps ease cravings and withdrawal symptoms without causing the “high” that comes with opioid misuse. Sublocade is a long-acting injection you get monthly, making it a convenient and reliable option for consistent treatment.
Key Points about Sublocade:
- Targets opioid use disorder symptoms specifically.
- You’ll need to be stabilized on oral buprenorphine (like Suboxone) before getting the injection.
- Given once a month to keep medication levels steady.
What is Vivitrol2?
Vivitrol is an injectable form of naltrexone that’s used to treat both alcohol and opioid use disorder. Rather than partially activating opioid receptors like Sublocade does, Vivitrol blocks opioid receptors in the brain. This stops the euphoric effects of alcohol or opioids, making it a great tool for preventing relapse by blocking the “rewards” that usually come with substance use. It’s important to note that both medications significantly reduce cravings.
Key Points about Vivitrol:
- Approved for both alcohol and opioid addiction.
- Patients need to fully detox (no opioids in their system) before the first injection to prevent precipitated withdrawal symptoms.
- Brief abstinence from alcohol is helpful but not mandatory
- Given once a month.
What is Brixadi³?
Brixadi is a newer extended-release buprenorphine treatment administered via injection. It offers both weekly and monthly dosing options, providing flexibility for different stages of recovery. Like Sublocade, it helps reduce cravings and withdrawal by partially stimulating opioid receptors, but its dosing flexibility lets clinicians tailor treatment more closely to a patient’s needs.
Key Points about Brixadi:
- Targets opioid use disorder symptoms specifically.
- Flexible dosing available in weekly or monthly options.
- Partial receptor activation to manage cravings and withdrawal.
- Adaptive timing ideal for stabilization or transitioning between treatment stages.
Sublocade vs. Vivitrol vs. Brixadi: Which is Right for You?
Sublocade, Vivitrol, and Brixadi each offer powerful paths to recovery—but they differ in how they work, how often they’re given, and which patients they best serve. It’s essential to choose the right one based on a person’s recovery stage, treatment goals, and clinical needs.
Consider:
- Substance of choice (opioids vs. alcohol/opioids).
- Detox requirements (brief abstinence needed for Sublocade and Brixadi; full detox required for Vivitrol).
- Medical history and risk of relapse.
Conclusion:
Each medication can be great options for supporting recovery. At Pinnacle, we focus on evidence-based treatments to help people overcome substance use disorders. Want to learn more about using Sublocade, Vivitrol, or Brixadi in your recovery? Give us a call at 888-991-7351 or reach out through our website—we’re here to help!
As always, a personalized evaluation by a medical professional is key to determining the best approach for long-term success. We’re here to guide you toward a healthier, substance-free life.
References
1. U.S. Food and Drug Administration. (2017). Sublocade (Buprenorphine Extended-Release) Injection. FDA Label
2. U.S. Food and Drug Administration. (2010). Vivitrol (Naltrexone for Extended-Release Injectable Suspension). FDA Label
3. U.S. Food and Drug Administration. (2023). Brixadi (Buprenorphine Extended-Release) Injection. FDA Label
Disclaimer: The content provided is for informational purposes only and should not be considered medical advice. Always consult a qualified healthcare provider regarding any questions about your medical condition or treatment.
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