By Dr. Chris Dennis | Chief Medical Officer
Sublocade vs. Vivitrol: Key Differences Explained
When it comes to treating opioid use disorder, medications like Sublocade and Vivitrol often come up. Both can be effective, but they work in very different ways. Let’s break down the difference between Sublocade and Vivitrol to help patients, families, and professionals make informed choices.
What is Sublocade1?
Sublocade is an injectable form of buprenorphine that helps treat opioid use disorder. It works by partially activating opioid receptors in the brain, which helps ease cravings and withdrawal symptoms without causing the “high” that comes with opioid misuse. Sublocade is a long-acting injection you get monthly, making it a convenient and reliable option for consistent treatment.
Key Points about Sublocade:
- Targets opioid use disorder symptoms specifically.
- You’ll need to be stabilized on oral buprenorphine (like Suboxone) before getting the injection.
- Given once a month to keep medication levels steady.
What is Vivitrol2?
Vivitrol is an injectable form of naltrexone that’s used to treat both alcohol and opioid use disorder. Rather than partially activating opioid receptors like Sublocade does, Vivitrol blocks opioid receptors in the brain. This stops the euphoric effects of alcohol or opioids, making it a great tool for preventing relapse by blocking the “rewards” that usually come with substance use. It’s important to note that both medications significantly reduce cravings.
Key Points about Vivitrol:
- Approved for both alcohol and opioid addiction.
- Patients need to fully detox (no opioids in their system) before the first injection to prevent precipitated withdrawal symptoms.
- Brief abstinence from alcohol is helpful but not mandatory
- Given once a month.
Sublocade vs. Vivitrol: Which is Right for You?
The main difference between Sublocade and Vivitrol is how they work with opioid receptors. Sublocade partially activates receptors to help reduce cravings and withdrawal symptoms, while Vivitrol blocks them entirely without any receptor activation. The best choice depends on the patient’s substance use history and recovery goals.
Consider:
- Substance of choice (opioids vs. alcohol/opioids).
- Detox requirements (brief abstinence needed for Sublocade; full detox required for Vivitrol).
- Medical history and risk of relapse.
Conclusion:
Sublocade and Vivitrol can both be great options for supporting recovery. At Pinnacle, we focus on evidence-based treatments to help people overcome substance use disorders. Want to learn more about using Sublocade or Vivitrol in your recovery? Give us a call at 888-991-7351 or reach out through our website—we’re here to help!
As always, a personalized evaluation by a medical professional is key to determining the best approach for long-term success. We’re here to guide you toward a healthier, substance-free life.
References
1. U.S. Food and Drug Administration. (2017). Sublocade (Buprenorphine Extended-Release) Injection. FDA Label
2. U.S. Food and Drug Administration. (2010). Vivitrol (Naltrexone for Extended-Release Injectable Suspension). FDA Label
Disclaimer: The content provided is for informational purposes only and should not be considered medical advice. Always consult a qualified healthcare provider regarding any questions about your medical condition or treatment.
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